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KMID : 0043320080310080965
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Archives of Pharmacal Research
2008 Volume.31 No. 8 p.965 ~ p.969
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A New Cytotoxic Prenylated Dihydrobenzofuran Derivative and Other Chemical Constituents from the Rhizomes of Atractylodes lancea DC
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Duan Jin Ao
Wang Liuying
Qian Shihui
Su Shulan
Tang Yuping
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Abstract
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A new prenylated dihydrobenzofuran derivative (1), was isolated from the rhizomes of Atractylodes lancea DC (Asteraceae), along with ten known compounds, including atractylenolide II (2), -taraxasteryl acetate (3), taraxerol acetate (4), -sitosterol (5), stigmasterol (6), -eudesmol (7), atractylenolide III (8), atractylenolide IV (9), daucosterol (10), and stigmasterol 3-O--D-glucopyranoside (11). The structure of the new compound (1) was elucidated as trans-2-hydroxyisoxypropyl-3-hydroxy-7-isopentene-2,3-dihydrobenzofuran-5-carboxylic acid by the combination of 1D, 2D NMR analysis and mass spectrometry, and it was the first reported 2,3-dihydrobenzofuran derivative having a carboxyl residue at C-5 and an isopentene moiety at C-7 contemporaneously. In addition, compound 1 exhibited significant cytotoxicity against cancer cell lines HCT-116 and MKN-45.
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KEYWORD
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Atractylodes lancea, Asteraceae, Constituent, Atractylenolide, Dihydrobenzofuran, Cytotoxicity
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